个人简介
姓名：陈文利
学历：博士研究生
职称：三级教授、博士生导师
职务：-
研究方向：自噬基因功能研究
联系电话：020-85211421-8512
电子邮箱：chenwl@scnu.edu.cn
通讯地址：广州石牌华南师范大学激光生命研究所（邮编 510631
陈文利，博士生导师、三级教授。2002年获光学博士学位。2002.5—2003.1德国国际生物物理研究所从事生物光子学的研究 (合作教授Fritz-Albert Popp & Roeland Van Wijk)，在柏林自由大学的生物化学与分子生物学研究所(合作教授Werner Reutter & Hua Fan)从事分子生物学方面的实验研究 (作为访问学者获DAAD资助)；2011.12—2013.4在美国杜克大学环境学院(Nicholas School of the Environment) Xinnian Dong实验室访学；2013.5—2016.2在美国北卡罗来纳大学教堂山分校(UNC at Chapel Hill)生物学系Alan M. Jones实验室、生物化学与生物物理系Hengming Ke实验室从事合作研究。近年主要专注纳米材料在动植物体内的应用基础研究：在柑橘黄龙病早期大田检测、AI在柑橘黄龙病智能检测预警体系的应用潜力挖掘、中药和土壤有益微生物防治柑橘黄龙病、纳米转基因技术在柑橘遗传转化中的应用研究。在《Autophagy》, 《Sensors and Actuators B: Chemical》, 《iScience》等期刊上发表40多篇SCI收录的研究论文，承担并结题了国家自然科学基金项目2项。研究方向：（1）自噬相关基因的功能研究； （2）纳米转基因技术在植物及动物体内的应用基础研究；学习经历：2013.5—2014.4美国北卡罗来纳大学教堂山分校(UNC at Chapel Hill)生物学系从事自噬在饥饿与糖诱导下在G蛋白信号转导调节因子（RGS）合成和降解的作用研究。访问学者 2011.12—2013.4美国杜克大学环境学院（Nicholas School of the Environment）从事植物抗病过程中自噬基因功能的合作研究 。访问学者 2002. 5—2003.1德国国际生物物理研究所从事生物光子学的研究,在柏林自由大学生物化学与分子生物学研究所从事分子生物学方面的实验研究（作为访问学者获DAAD资助） 1999.9—2002.12华南师范大学激光生命研究所，获博士学位 1994.9—1997.6南京农业大学生命科学学院，获硕士学位工作经历：1997.8—至今华南师范大学生命科学学院/生物光子学研究院系助教，讲师，副教授，教授。从事生物化学、细胞生物学的研究及教学工作。学术兼职：曾担任国际刊物Journal of Chromatography A，Luminescence，Human and Experimental Toxicology，Molecular Biotechnology等的审稿人。
已发表研究论文：1. Jingfeng weng, Junzhe Zhang, Jin Lv, Chengqian Zhou, Jun Yuan, Min Wang, Dongqing Xu, Yun Zhong, Wenli Chen. Effective detection of early Citrus Huanglongbing by polyehtyleneimine modified multi-walled carbon nanotubes gas sensor. Sensor and Actuators B: Chemical, Volume 371, 2022, 132508, ISSN 0925, https://doi.org/10.1016/j.snb.2022.132508. (Correspondence author) 2. Zhang J, Lei W, Meng Y, Zhou C, Zhang B, Yuan J, Wang M, Xu D, Meng X, Chen W. Expression of PEI-coated gold nanoparticles carrying exogenous gene in periwinkle mesophyll cells and its practice in huanglongbing research. iScience. 2022 May 29;25(6):104479. doi: 10.1016/j.isci.2022.104479. PMID: 35712078; PMCID: PMC9192802. (Correspondence author) 3. Huang C, Huang W, Zhang L, Zhang C, Zhou C, Wei W, Li Y, Zhou Q, Chen W, Tang Y. Targeting Peptide, Fluorescent Reagent Modified Magnetic Liposomes Coated with Rapamycin Target Early Atherosclerotic Plaque and Therapy. Pharmaceutics. 2022 May 18;14(5):1083. doi: 10.3390/pharmaceutics14051083. PMID: 35631669; PMCID: PMC9146689. 4. Zhang C, Huang W, Huang C, Zhou C, Tang Y, Wei W, Li Y, Tang Y, Luo Y, Zhou Q and ChenW(2022) VHPKQHR Peptide Modified Ultrasmall Paramagnetic Iron Oxide Nanoparticles Targeting Rheumatoid Arthritis for T1-Weighted Magnetic Resonance Imaging. Front. Bioeng. Biotechnol. 10:821256. doi: 10.3389/fbioe.2022.821256 (Correspondence author) 5. Huang W, Li X, Huang C, Tang Y, Zhou Q and Chen W (2022) LncRNAs and Rheumatoid Arthritis: From Identifying Mechanisms to Clinical Investigation. Front. Immunol. 12:807738. doi: 10.3389/fimmu.2021.807738 (Correspondence author) 6. An Zishuai, Cao Bing, Zhang Junzhe, Zhang Baihong, Zhou Chengqian, Hu Xianglong, Chen Wenli. Efficient Transient Expression of Plasmid DNA Using Poly (2-(N,NDimethylamino) Ethyl Methacrylate) in Plant Cells. Front. Bioeng. Biotechnol. 2022. 10:805996. doi: 10.3389/fbioe.2022.805996 (Correspondence author) 7. Li X, Ruan H, Zhou C, Meng X, Chen W. Controlling Citrus Huanglongbing: Green Sustainable Development Route Is the Future. Front Plant Sci. 2021 Nov 15;12:760481. doi: 10.3389/fpls.2021.760481. PMID: 34868155; PMCID: PMC8636133. (Correspondence author) 8. Huang, S.; Zhang, B.; Chen, W. Research Progress of ATGs Involved in Plant Immunity and NPR1 Metabolism. Int. J. Mol. Sci. 2021, 22, 12093. https://doi.org/10.3390/ijms222212093 (Correspondence author) 9. Duan J, Li X, Zhang J, Cheng B, Liu S, Li H, Zhou Q, Chen W. Cocktail Therapy of Fosthiazate and Cupric-Ammoniun Complex for Citrus Huanglongbing. Front Plant Sci. 2021 Mar 31; 12: 643971. doi: 10.3389/fpls.2021.643971. PMID: 33868341; PMCID: PMC8044827. (Correspondence author) 10. Gong W, Li B, Zhang B, Chen W. ATG4 Mediated Psm ES4326/AvrRpt2-Induced Autophagy Dependent on Salicylic Acid in Arabidopsis Thaliana. Int J Mol Sci. 2020 Jul 21;21(14):5147. doi: 10.3390/ijms21145147. PMID: 32708160; PMCID: PMC7404177. (Correspondence author) 11. Lei, W.X., An, Z.S., Zhang, B.H., Wu, Q., Gong, W.J., Li, J.M., Chen, W.L. 2020. Construction of gold-siRNA NPR1 nanoparticles for effective and quick silencing of NPR1 in Arabidopsis thaliana. RSC Advances, 10, 19300-19308. (Correspondence author) 12. Jiao Y, Srba M, Wang J, Chen W. Correlation of Autophagosome Formation with Degradation and Endocytosis Arabidopsis Regulator of G-Protein Signaling (RGS1) through ATG8a. Int J Mol Sci. 2019 Aug 27;20(17):4190. doi: 10.3390/ijms20174190. PMID: 31461856; PMCID: PMC6747245. (Correspondence author) 13. Zhang S, Xu W, Gao P, Chen W, Zhou Q. Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):169-179. 14. Xu W, Zhang S, Zhou Q, Chen W. VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2440-2448. doi: 10.1080/21691401.2019.1626411. PMID: 31190559. (Correspondence author) 15. Jiao Y, Lei W, Xu W, Chen WL. Glucose signaling, AtRGS1 and plant autophagy. Plant Signal Behav. 2019;14(7):1607465. doi: 10.1080/15592324.2019.1607465. Epub 2019 May 6. PMID: 31055999; PMCID: PMC6619941. (Correspondence author) 16. Zhang W, Xu W, Chen W, Zhou Q. Interplay of Autophagy Inducer Rapamycin and Proteasome Inhibitor MG132 in Reduction of Foam Cell Formation and Inflammatory Cytokine Expression. Cell Transplant. 2018 Aug;27(8):1235-1248. doi: 10.1177/0963689718786229. Epub 2018 Jul 12. PMID: 30001636; PMCID: PMC6434468. (Correspondence author) 17. Yan Q, Wang J, Fu ZQ, Chen W. Endocytosis of AtRGS1 Is Regulated by the Autophagy Pathway after D-Glucose Stimulation. Front Plant Sci. 2017 Jul 12;8:1229. doi: 10.3389/fpls.2017.01229. PMID: 28747924; PMCID: PMC5506085. (Correspondence author) 18. Zhang W, Zhang S, Xu W, Zhang M, Zhou Q, Chen W. The function and magnetic resonance imaging of immature dendritic cells under ultrasmall superparamagnetic iron oxide (USPIO)-labeling. Biotechnol Lett. 2017 Jul;39(7):1079-1089. doi: 10.1007/s10529-017-2332-3. Epub 2017 Apr 10. PMID: 28396958. (Correspondence author) 19. 陈文利, 徐婉, 程保平, 彭埃天, 焦悦. 柑橘黄龙病检测及治疗方法的研究进展[J]. 华南师范大学学报（自然科学版）, 2017, 49(5): 9-15. （通讯作者） 20. 张伟, 陈文利, 周全, 闫劝劝. TOLL样受体9在动脉粥样硬化中的作用研究进展[J]. 2016 25 (4): 295-301. （通讯作者） 21. Gao YY, Wang XD, Ma C, Chen WL. EDS1-mediated activation of autophagy regulates Pst DC3000 (AvrRps4)-induced programmed cell death in Arabidopsis . Acta Physiol Plant 38, 150 (2016). https://doi.org/10.1007/s11738-016-2160-4 (Correspondence author) 22. Wang XD, Gao YY, Yan QQ, Chen WL. Salicylic acid promotes autophagy via NPR3 and NPR4 in Arabidopsis senescence and innate immune response. Acta Physiol Plant 38, 241 (2016). https://doi.org/10.1007/s11738-016-2257-9 (Correspondence author) 23. Liu HB, Wang XD, Zhang YY, Dong JJ, Ma C, Chen WL. NADPH oxidase RBOHD contributes to autophagy and hypersensitive cell death during the plant defense response in Arabidopsis thaliana . Biol Plant 59, 570–580 (2015). https://doi.org/10.1007/s10535-015-0519-9 (Correspondence author) 24. Wang J, Ma C, Zhang M, Yang L, Chen W. ATG5 is required to limit cell death induced by Pseudomonas syringae in Arabidopsis and may be mediated by the salicylic acid pathway. Acta Physiol Plant 37, 1731 (2015). https://doi.org/10.1007/s11738-014-1731-5 (Correspondence author) 25. Zhang M, Zhou J, Wang J, Zhou Q, Fang J, Zhou C, Chen W. Superparamagnetic iron oxide labeling limits the efficacy of rabbit immature dendritic cell vaccination by decreasing their antigen uptake ability in a lysosome-dependent manner. Biotechnol Lett. 2015 Feb;37(2):289-98. doi: 10.1007/s10529-014-1681-4. Epub 2014 Sep 26. PMID: 25257596. (Correspondence author) 26. Yu M, Wang J, Liu W, Qin J, Zhou Q, Wang Y, Huang H, Chen W, Ma C. Effects of tamoxifen on the sex determination gene and the activation of sex reversal in the developing gonad of mice. Toxicology. 2014 Jul 3;321:89-95. doi: 10.1016/j.tox.2014.04.006. Epub 2014 Apr 24. PMID: 24769059. 27. Zhou J, Yang F, Zhou Q, Yang K, Chen W. Magnetic resonance imaging tracking of ultra small superparamagnetic iron oxide labeled rabbit dendritic cells. Exp Biol Med (Maywood). 2014 Jan;239(1):13-23. doi: 10.1177/1535370213508712. Epub 2013 Nov 13. PMID: 24227632. (Correspondence author) 28. Dong J, Chen W. The role of autophagy in chloroplast degradation and chlorophagy in immune defenses during Pst DC3000 (AvrRps4) infection. PLoS One. 2013 Aug 30;8(8):e73091, 1-16. doi: 10.1371/journal.pone.0073091. PMID: 24023671; PMCID: PMC3758262. (Correspondence author) 29. Liang MJ, Zhou Q, Yang KR, Yang XL, Fang J, Chen WL, Huang Z. Identify changes of brain regional homogeneity in bipolar disorder and unipolar depression using resting-state FMRI. PLoS One. 2013 Dec 4;8(12):e79999, 1-8. doi: 10.1371/journal.pone.0079999. PMID: 24324588; PMCID: PMC3851159. 30. Yang FY, Yu MX, Zhou Q, Chen WL, Gao P, Huang Z. Effects of iron oxide nanoparticle labeling on human endothelial cells. Cell Transplant. 2012;21(9):1805-20. doi: 10.3727/096368912X652986. Epub 2012 Jul 5. PMID: 22776829. (Correspondence author) 31. Wenli Chen (one of authors). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496. PMID: 22966490; PMCID: PMC3404883. 32. Zhou Q, Yang KR, Gao P, Chen WL, Yang DY, Liang MJ, Zhu L. An experimental study on MR imaging of atherosclerotic plaque with SPIO marked endothelial cells in a rabbit model. J Magn Reson Imaging. 2011 Dec;34(6):1325-32. doi: 10.1002/jmri.22756. Epub 2011 Sep 23. PMID: 21953575. 33. Zhang W, Chen W. Role of salicylic acid in alleviating photochemical damage and autophagic cell death induction of cadmium stress in Arabidopsis thaliana. Photochem Photobiol Sci. 2011 Jun;10(6):947-55. doi: 10.1039/c0pp00305k. Epub 2011 Feb 18. PMID: 21336371. (Correspondence author) 34. Yun LJ, Chen WL. SA and ROS are involved in methyl salicylate-induced programmed cell death in Arabidopsis thaliana. Plant Cell Rep. 2011 Jul;30(7):1231-9. doi: 10.1007/s00299-011-1031-0. Epub 2011 Feb 17. PMID: 21327960. (Correspondence author) 35. Chen ZQ, Chen WL, Yang CW. [Effects of exogenous salicylic acid on photosynthesis in Arabidopsis leaves based on fluorescence spectra and delayed fluorescence technique]. Guang Pu Xue Yu Guang Pu Fen Xi. 2009 Aug;29(8):2208-12. Chinese. PMID: 19839340. (Correspondence author) 36. Liu Yang, Junjian Dong, Wenli Chen*. Autophagy and declined photosynthesis in Arabidopsis during pathogenic Pst DC3000 infection. Acta Biophysica Sinica. 2011, 27(6):517-527. (in Chinese) (Correspondence author) 37. Gao Lin, Zhang Weina, Chen Wenli*. Cadmium toxicity and autophagy in Arabidopsis seedlings.Acta Biophysica Sinica. 2011, 27(8):676-686. (in Chinese) (Correspondence author) 38. Yu MX, Chen WL, Zhou Q, Gao P. Study on ASTC-a-1 cells labeled with superparamagnetic iron oxide and its magnetic resonance imaging. Exp Biol Med (Maywood). 2010 Sep;235(9):1053-61. doi: 10.1258/ebm.2010.010058. Epub 2010 Aug 18. PMID: 20719819. (Correspondence author) 39. Bi Y, Chen W, Zhang W, Zhou Q, Yun L, Xing D. Production of reactive oxygen species, impairment of photosynthetic function and dynamic changes in mitochondria are early events in cadmium-induced cell death in Arabidopsis thaliana. Biol Cell. 2009 Aug 19;101(11):629-43. doi: 10.1042/BC20090015. PMID: 19453296. (Correspondence author) 40. Zhou Q, Dong Y, Huang L, Yang S, Chen W. Study of cerebrovascular reserve capacity by magnetic resonance perfusion weighted imaging and photoacoustic imaging. Magn Reson Imaging. 2009 Feb;27(2):155-62. doi: 10.1016/j.mri.2008.07.002. Epub 2008 Aug 12. PMID: 18701227. 41. Chen WL, Xing D, Wijk RV. Chemiluminescence during rice seed imbibition at different temperatures. Luminescence. 2006 Jan-Feb;21(1):31-5. doi: 10.1002/bio.879. PMID: 16100741. (Correspondence author) 42. Chen W, Xing D, Chen W. Rapid detection of Aspergillus flavus contamination in peanut with novel delayed luminescence spectra. Photochem Photobiol. 2005 Nov-Dec;81(6):1361-5. doi: 10.1562/2005-05-23-RC-538. PMID: 16354112. (Correspondence author) 43. Chen WL, Van Wijk R, Xing D. Effects of isoflurane on measurements of delayed lumininescence in Acetabularia acetabulum. Luminescence. 2005 Jan-Feb;20(1):16-9. doi: 10.1002/bio.794. PMID: 15685666. (Correspondence author) 44. Chen WL, Xing D, Tan S, Tang Y, He Y. Imaging of ultra-weak bio-chemiluminescence and singlet oxygen generation in germinating soybean in response to wounding. Luminescence. 2003 Jan-Feb;18(1):37-41. doi: 10.1002/bio.703. PMID: 12536378. 45. Chen W, Xing D, Wang J, He Y. Rapid determination of rice seed vigour by spontaneous chemiluminescence and singlet oxygen generation during early imbibition. Luminescence. 2003 Jan-Feb;18(1):19-24. doi: 10.1002/bio.695. PMID: 12536375.
科研项目：1，自噬与NPR1、NPR3和NPR4之间的相互作用研究(31570256)，国家自然科学基金面上项目，2016.1－2019.12;75万（直接费用63万，间接费用12万）,主持 2，超小超顺磁性氧化铁标记树突状细胞对兔动脉粥样硬化的磁共振成像研究（81471659），国家自然科学基金面上项目，2015.1－2018.12; 73万,[合作课题，华南师大负责人] 3，超敏反应初期NPR1与自噬小体之间的关系研究（2014A030313420），广东省自然科学基金项目，2015.1-2018.1，10万,主持 4，Pst DC3000(avrRps4/avrB)侵染植株引起超敏反应初期自噬在NADPH氧化酶途径和叶绿体降解中的角色（31170250），国家自然科学基金面上项目，2012.1－2015.12; 55万,主持
主要获奖：1，《生物光子学的基础与应用研究》获2006年度广东省科学技术奖一等奖(排名第四)。 2，2006年-2010年为广东省高等学校"千、百、十"工程（校级）培养对象。 3，2005年广东省科学技术奖一等奖“生物光子学的基础与应用研究”的主要参与者（排名第四）。 4，2004年获得“为了明天”双语教学比赛一等奖（校级） 5，2006年获得“为了明天”教学比赛一等奖的第一名（校级）