个人简介
姓名：黎锦明
学历：博士
职称：研究员
研究方向：无机纳米材料在肿瘤/干细胞治疗中的应用
电子邮箱：lijinm@scnu.edu.cn
教育及工作经历：
2012.6博士毕业于中山大学化学院，获理学博士学位。
2012.9-2014.2 新加坡南洋理工大学 博士后
2014.2-2016.8 香港中文大学 博士后
2016.8-2017.8 加州大学河滨分校 博士后
2017.9-至今 华南师范大学生物光子学研究院 研究员
发表论文：
目前为止，已在Nano Lett., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Funct. Mater., Biomaterials, ACS Appl. Mater. Interfaces, Adv. Healthcare Mater., Nanoscale, J. Mater. Chem. B等著名杂志期刊发表SCI论文28篇，他引600多次，H=10。（#共同第一作者，*通讯作者）
2020年
1. Qian Wu, Kaipeng Wang, Xichao Wang, Guohai Liang* and Jinming Li*. Delivering siRNA to control osteogenic differentiation and real-time detection of cell differentiation in human mesenchymal stem cells using multifunctional gold nanoparticles. J.Mater. Chem. B, 2020, 8, 3016.
2. Kaipeng Wang, Qian Wu, Xichao Wang, Guohai Liang, Anli Yang* and Jinming Li*. Near-infrared control and real-time detection of osteogenic differentiation in mesenchymal stem cells by multifunctional upconversion nanoparticles. Nanoscale, 2020, 12, 10106.
3. Wen-Xue Lei, Zi-Shuai An, Bai-Hong Zhang, Qian Wu, Wen-Jun Gong, Jin-Ming Li* and Wen-Li Chen*. Construction of gold-siRNA NPR1 nanoparticles for effective and quick silencing of NPR1 in Arabidopsis thaliana. RSC Adv., 2020, 10, 19300.
2019年
1. Jinming Li,# Chris Wai Tung Leung,# Dexter Siu Hong Wong, Jianbin Xu, Rui Li, Yueyue Zhao, Chris Yu Yee Yung, Engui Zhao, Ben Zhong Tang* and Liming Bian*. Photocontrolled SiRNA Delivery and Biomarker-Triggered Luminogens of Aggregation-Induced Emission by Up-Conversion NaYF4:Yb3+Tm3+@SiO2 Nanoparticles for Inducing and Monitoring Stem-Cell Differentiation. ACS Appl. Mater. Interfaces 2019, 11, 22074−22084.
2. Jianbin Xu, Qian Feng, Sien Lin, Weihao Yuan, Rui Li, Jinming Li, Kongchang Wei, Xiaoyu Chen, Kunyu Zhang, Yanhua Yang, Tianyi Wu, Bin Wang, Meiling Zhu, Rui Guo, Gang Li* and Liming Bian*. Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules. Biomaterials 210 (2019) 51-61.
2018年
1. Rui Li,# Jinming Li,# Jianbin Xu, Dexter Siu Hong Wong, Xiaoyu Chen, Weihao Yuan, Liming Bian*. Multiscale reconstruction of a synthetic biomimetic micro-niche for enhancing and monitoring the differentiation of stem cells. Biomaterials 173 (2018) 87-99.
2. Jinming Li,# Honghong Wu,# Israel Santana, Mackenzie Fahlgren, and Juan Pablo Giraldo*. Standoff Optical Glucose Sensing in Photosynthetic Organisms by a Quantum Dot Fluorescent Probe. ACS Appl. Mater. Interfaces 2018, 10, 28279−28289.
3. Jinming Li,# Wayne Yukwai Lee,# Tianyi Wu, Chris Waitung Leung, Jianbin Xu, Dexter Siuhong Wong, Rui Li, Gang Li,* Ben Zhong Tang,* and Liming Bian*. Detection of Matrix Metallopeptidase 13 for Monitoring Stem Cell Differentiation and Early Diagnosis of Osteoarthritis by Fluorescent Light-Up Probes with Aggregation-Induced Emission Characteristics. Adv. Biosys. 2018, 1800010.
4. Heemin Kang, Kunyu Zhang, Qi Pan, Sien Lin, Dexter Siu Hong Wong, Jinming Li, Wayne Yuk-Wai Lee, Boguang Yang, Fengxuan Han, Gang Li, Bin Li,* and Liming Bian*. Remote Control of Intracellular Calcium Using Upconversion Nanotransducers Regulates Stem Cell Differentiation In Vivo. Adv. Funct. Mater. 2018, 1802642.
2017年
1. Dexter S. H. Wong,# Jinming Li,# Xiaohui Yan, Ben Wang, Rui Li, Li Zhang, and Liming Bian*. Magnetically Tuning Tether Mobility of Integrin Ligand Regulates Adhesion, Spreading, and Differentiation of Stem Cells. Nano Lett. 2017, 17, 1685−1695.
2. Rui Li, Jianbin Xu, Dexter Siu Hong Wong, Jinming Li, Pengchao Zhao, Liming Bian*. Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/ b -catenin signaling. Biomaterials 145 (2017) 33-43.
2016年
1. Jinming Li, Wayne Yukwai Lee, Tianyi Wu, Jianbin Xu, Kunyu Zhang, Gang Li, Jiang Xia, and Liming Bian*. Multifunctional Quantum Dot Nanoparticles for Effective Differentiation and Long-Term Tracking of Human Mesenchymal Stem Cells In Vitro and In Vivo. Adv. Healthcare Mater. 2016, 5, 1049-1057.
2. Jianbin Xu,# Jinming Li,# Sien Lin, Tianyi Wu, Heqin Huang, Kunyu Zhang, Yuxin Sun, Kelvin W. K. Yeung, Gang Li, and Liming Bian*. Nanocarrier-Mediated Codelivery of Small Molecular Drugs and siRNA to Enhance Chondrogenic Differentiation and Suppress Hypertrophy of Human Mesenchymal Stem Cells. Adv. Funct. Mater. 2016, 26, 2463-2472.
3. Jinming Li,# Yuanyuan Wang,# Shanshan Xue, Jinghua Sun, Wei Zhang, Ping Hu, Liangnian Ji, Zongwan Mao*. Effective combination treatment of lung cancer cells by single vehicular delivery of siRNA and different anticancer drugs. Int. J. Nanomed. 2016, 11, 4609-4624.
4. Jinming Li, Shanshan Xue and Zong-Wan Mao.* Nanoparticle delivery systems for siRNA-based therapeutics. J. Mater. Chem. B 2016, 4, 6620.
5. Jinming Li,# Wayne Yukwai Lee,# Tianyi Wu, Jianbin Xu, Kunyu Zhang, Dexter Siu Hong Wong, Rui Li, Gang Li,* Liming Bian.* Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles. Biomaterials 2016, 110, 1-10.
2015年
1. Jinming Li, Wei Zhang, Liangnian Ji and Zongwan Mao.* Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNAusing a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier. Int. J. Nanomed. 2015, 10, 3147-3162.
2. Chun Kit Choi, Jinming Li, Kongchang Wei, Yang J. Xu, Lok Wai C. Ho, Meiling Zhu, Chung Hang J. Choi* and Liming Bian.* A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells. J. Am. Chem. Soc. 2015, 137, 7337.
2014年
1. Jinming Li, Fang Liu, Qing Shao , Yuanzeng Min , Marianne Costa, Edwin K. L.Yeow* and Bengang Xing.* Enzyme-responsive cell-penetrating peptide conjugated mesoporous silica quantum dot nanocarriers for controlled release of nucleus-targeted drug molecules and real-time intracellular fluorescence imaging of tumor cells. Adv. Healthcare Mater. 2014, 3, 1230-1239.
2. Yuanzeng Min, Jinming Li, Fang Liu and Bengang Xing.* Near-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticles. Angew. Chem. Int. Ed. 2014, 53, 1012-1016.
3.Yuanzeng Min, Jinming Li, Fang Liu and Bengang Xing.* Recent advance of biological molecular imaging based on lanthanide-doped upconversion-luminescent nanomaterials. J. Nanomater. 2014, 4, 129-154.
4. Meixia Zhao, Meng Zhao, Erzao Zeng, Yang Li, Jinming Li, Qian Cao, Caiping Tan, Liangnian Ji, Zongwan Mao.* Enhanced anti-cancer efficacy to cancer cells by doxorubicin loaded water-soluble amino acid-modified β- cyclodextrin platinum complexes. J. Inorg. Biochem. 2014, 137, 31-39.
2013年
1.Jinming Li, Yuanyuan Wang, Wei Zhang, Liangnian Ji and Zongwan Mao.* Lowweight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA. Int. J. Nanomed. 2013, 8, 2101-2117.
2.Ling Zhang, Qihe Yin, Jinming Li, Hongying Huang, QingWu and Zongwan Mao.* Functionalization of dendritic polyethylene with cationic poly(p-phenylene ethynylene) enables efficient siRNA delivery for gene silencing. J. Mater. Chem. B 2013, 1, 2245-2251.
2012年
Jinming Li,# Yuanyuan Wang,# Caiping Tang, Liangnian Ji and Zongwan Mao.* Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking. Biomaterials 2012, 33, 2780-2790.
2011年
1. Jinming Li, Meixiao Zhao, Caiping Tang, Liangnian Ji and Zongwan Mao.* Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Biomaterials 2011, 32, 7978-7987.
2. Meixia Zhao, Jinming Li, Caiping Tang, Liangnian Ji and Zongwan Mao.* Targeted cellular uptake and siRNA silencing by quantum-dot nanoparticles coated with β-cyclodextrin coupled to amino acids. Chem-Eur J. 2011, 17, 5171-5179.
科研项目：
2017年华南师范大学青年拔尖人才科研启动基金，8S0143，150万，主持，在研。
2019年国家自然科学基金面上项目，上转换纳米粒光控诱导干细胞分化及检测分化用于骨质疏松治疗研究，项目批准号：31971267，58万，主持，在研。