个人简介
姓名:杨思华
学历:博士
职称:研究员(博士生导师)
职务:副院长、重点实验室主任
研究方向:生物医学光子学、激光医学影像、光声成像
联系电话:020-85211436-8201
电子邮箱:yangsh@scnu.edu.cn
通讯地址:广州市石牌华南师范大学生物光子学研究院(510631)
工作经历:
华南师范大学 研究员 / 博士生导师
生物光子学研究院 副院长
激光生命科学教育部重点实验室 主 任
广东省新型超声成像设备工程技术研发中心 主 任
华南师范大学物理学部学术委员会 副主任委员
国家优秀青年科学基金获得者、广东特支计划科技创新青年拔尖人才、广东省高等学校优秀青年教师(培养计划);目前研究领域是显微光声成像技术、光声内窥镜技术及其应用仪器开发;超短脉冲(微波)热弹冲击波治疗技术及其医学应用研究。主要研究成果包括:开拓了基于血红蛋白及功能分子的多尺度光声成像医学转化应用研究,实现了无损无创的人体皮肤真皮深层高分辨的畸形血管显微检测,突破了现有医学影像技术在皮肤高分辨率(< 50 μm)检测中的深度极限(> 1 mm),研发的皮肤光声显微成像仪,获国家药监局创新医疗器械认定(2017.2),及医疗器械注册许可证(2020.1);提出多波长光声血管内脂质组分定量成像识别斑块易损性的原创思想,实验演示了活体动物血管内斑块脂质核的高分辨率光声成像,弥补解决传统血管内影像方法无法高分辨可视化斑块脂质三维形貌和空间分布的难题,为深入理解和揭示心血管疾病的发病机制,寻找心脑血管内易损斑块早期诊断提供新的技术和手段;提出利用光声信号相位信息实现组织粘弹特性成像的思想,率先建立光声粘弹性成像理论模型,发明了基于光声位相检测的光声粘弹成像技术,继而扩展至光声多模态内窥镜应用研究中,研发了集表面光学成像、表面粘弹光声成像、深层微血管光声成像和组织分层超声成像于一体的消化道全壁影像技术仪器,开展新技术应用的临床研究。2018年获国家自然科学基金优秀青年基金;2016年获广东特支计划科技创新青年拔尖人才、广东省高等学校优秀青年教师(培养计划)。主持国家科技部“863”青年科学家专项、国家自然科学基金重点项目(合作)、面上项目、广东省自然科学基金重点项目、广东省产学研项目、广州市产学研重大项目等;发表研究论文120多篇,代表性论文有Journal of the American College of Cardiology, Physical Review Letter, Nano Lett, IEEE TMI, Nanophotonics, Small, Theranostics, Optics Letter, Appl Phys Lett等,H-index 23;主编教材《Biomedical Photoacoustics》1本;授权国家发明专利27项(第一发明人)。在光声成像技术方面曾获中国产学研合作创新奖(2021年)、广东省百名博士博士后创新人物(2021年)、育部高等学校科学研究优秀成果奖二等奖 (2013年)、广东省科学技术奖(发明类)二等奖 (2009年)、美国医学物理学会“Sylvia Sorkin Greenfield Award”奖 (2008年)、中国光学重要成果奖 (2008年)。
◆ 主要研究方向及内容
(1)光声脑功能成像与新型光-声调控
理解大脑的结构和功能是脑科学研究的重要方向之一,本方向致力于发展基于光声成像技术的大视野、高分辨、多功能脑成像技术平台,探索大脑微环境时空发展特性,利用脑疾病模型寻找新型成像标志物,研究脑脉管系统结构与功能参数和血脑屏障、 神经退行性疾病等脑疾病的关联性;利用光声效应发展新型光学与声学脑神经调控技术, 利用脉冲激光照射脑部内源/外源性吸收体,精准实现脑区深部神经核团刺激,为行为学研究及神经疾病的治疗提供新技术。
(2)偏振光声与生物基础交叉
偏振光声与生物学基础交叉融合,研究疾病影响下的亚细胞分子构象-单细胞形态-组织器官结构的异质性,理解疾病发展的结构特征,实现疾病的早期诊断。包括:(1)跨尺度光声肿瘤活检系统和功能识别。基于多光谱偏振光声技术实现细胞核-细胞质基质-微血管跨尺度、多参数表征肿瘤发展特征。利用一体化多波段光纤延时,实现单次扫描即可得到多参数成像。(2)基于偏振光声技术成像脑结构与功能。主要聚焦神经退行性疾病(包括阿尔茨海默病AD,帕金森病PD,肌萎缩侧索硬化症ALS等)导致的脑结构的变化实现对疾病的早期诊断基于现在的光声穆勒矩阵成像AD淀粉样蛋白的基础进一步发展全脑高分辨多光谱偏振光声成像系统(声分辨显微模式看微细结构或PACT模式实现实时监控)。发展一种基于偏振光声成像技术的脑结构和功能影像技术,在老鼠身上实现对多种神经退行性疾病的早期诊断。(3)开发新成像技术,如偏振超分辨技术、偏振光声光谱技术的研发、偏振光声遥感技术。
(3)深层微血管无创增强现实可视化系统与机器学习
针对光声层析成像中探测器带宽有限、接收角度有限等问题,研究物理模型与传统时域、频域重建算法的参数适配,开发基于深度学习融合物理模型的新型重建算法,实现高分辨、高信噪比的三维成像;改善光声阵列成像系统的各项参数指标,如系统分辨率、成像深度、成像速度。设计研发高分辨率投影式增强现实系统,将光声阵列成像系统与投影式增强现实系统结合,利用投影式增强现实系统的高分辨率投影能力,将光声阵列成像的高分辨率图像投影至真实手术解剖面,用于术前精准血管定位以及术中血管精准可视化导航。
(4)高分辨光声超声生物显微镜设计开发
(1)结构光超分辨光声显微镜。系统由正弦结构光激发模块及超声线阵探测器接收模块构成。系统通过多组不同频率正弦条纹结构光激发样品,进而对样品光声信号谱进行调制,并通过移动结构光相位以重构样品吸收谱。系统通过设计探测器传递函数对光声信号谱进行有效采集。最终对重构的样品吸收谱进行傅里叶逆变换即可反演出样品吸收分布。(2)皮肤高频超声诊断系统。对标德国TPM公司DUB系列皮肤超声,系统采用手持式单阵元机械线扫探头,系统接收支持光声链路(预留光声模块扩展)。系统支持不同中心频率探头,覆盖频率范围15MHz-75MHz;成像深度3mm-20mm,应用检查部位:皮肤、浅表等组织;轴向分辨率21μm-72μm。为皮肤科和医学美容医生提供超声(可扩展多种功能)影像可视化及量化分析手段。
(5)光声医学转化仪器开发组
将发展成熟的光声成像技术与光学成像、超声成像技术结合,做出以光声成像技术为核心的商业化的、产业化的光学/光声/超声多模态设备,推进组内光声技术在科研领域和医学领域的转化。涉及工作主要包括:结构设计(solidworks、CROE等软件使用;光学与超声参数设计)、FPGA与电路板的设计开发(verilog编程:电机运动控制与激发采集同步的设计与实现 )、软件工程(VS+QT框架:后端c++代码编程;前端外观美化设计与实现)、设备调试相关工作(激光光纤耦合的调试;动物、人体实验的设计与操作;实验结果整理与总结)等。
(6)多模态功能内窥镜组
开展与现有临床内窥镜结合的多模态功能影像技术,以临床柔性电子内镜和腹腔镜为原型,兼容式赋能多模态影像功能,包括:白光、超声、光学相干断层、光声、光声弹性。多模态功能内窥镜弥补单一成像模态成像分辨率、特异性、成像深度等方面的不足,获取多模态、跨尺度的影像学信息。此外,创新开发非接触遥感光声、光声弹性成像、光热相干层析位相分辨的深度粘弹成像技术,实现内窥模式下非接触光声、光声弹性以及组织深度粘弹的检测。光纤共振扫描器、特殊换能器、合成孔径等器件算法的开发研制极大改善了内窥成像信噪比、分辨率和系统稳定性。
◆ 学术任职
中国光学学会生物医学光子学专委会-副主任委员、
中华医学会激光医学分会基础与计量安全防护学组副组长、
广东省生物物理学会理事长、
中国医学装备协会超声装备技术分会-委员、
中国医学装备协会超声装备技术分会超声换能器及材料专委会-常务委员
中国生物医学工程学会青委会委员、
广州市仪器仪表学会-理事、
《激光生物学报》副主编、
《Chinese Optics Letters》主题编辑、
《Frontiers of Optoelectronics》编委、
广东省药品监督管理局医疗器械注册许可专家、
第九届广东省科协委员暨第五届广东省青年科学家协会常务理事、
SPIE Photonics West:Biophotonics and Immune Responses-
Program Committee
发表论文:
2021年:
Zhiyang Wang,Fei Yang,Haigang Ma,Zhongwen Cheng, Wuyu Zhang,Kedi Xiong,Tianding Shen, Sihua Yang*,Bifocal 532/1064 nm alternately illuminated photoacoustic microscopy for capturing deep vascular morphology in human skin,Journal of The European Academy of Dermatology and Venereology , 21 September 2021.
Dandan Cui, Yujiao Shi*, Da Xing, and Sihua Yang*,Ultrahigh Sensitive and Tumor-Specific Photoacoustography in NIRII Region: Optical Writing and Redox-Responsive Graphic Fixing by AgBr@PLGA Nanocrystals,Nano Letters,21 (16), 6914-6922 , 2021.
Zhiyang Wang,Fei Yang,Zhongwen Cheng,Wuyu Zhang,Kedi Xiong,Tianding Shen,Sihua Yang*,Quantitative multilayered assessment of skin lightening by photoacoustic microscopy,Quantitative Imaging in Medicine and Surgery, 12(1) , 2021.
HaiGang Ma,ZhongWen Cheng,ZhiYang Wang, HaiXia Qiu,TianDing Shen,Da Xing,Ying Gu,and Sihua Yang* ,Quantitative and anatomical imaging of dermal angiopathy by noninvasive photoacoustic microscopic biopsy,Biomedical Optics Express, 6300 , 2021.
Zhiyang Wang, Fei Yang, Zhongwen Cheng, Wuyu Zhang, Kedi Xiong and Sihua Yang*,Photoacoustic-guided photothermal therapy by mapping of tumor microvasculature and nanoparticle,Nanophotonics ,10(12): 3359–3368 , 2021.
Zhongwen Cheng , Haigang Ma, Zhiyang Wang, Wuyu Zhang, Fei Yang, and Sihua Yang*,Subpixel and On-Line Motion Correction for Photoacoustic Dermoscopy,IEEE Journal of Selected Toptics in Quantum Electronics, 27(4), 6800408, 2021.
Daocheng Zhang, Zhiyang Wang, Zhongwen Cheng, Wuyu Zhang, Fei Yang, and Sihua Yang*,An Ellipsoidal Focused Ultrasound Transducer for Extend-focus Photoacoustic Microscopy,IEEE Transactions on Biomedical Engineering , 3078729, 2021
Ting Guo, Kedi Xiong*, Zixin Zhang,Ling Li, and Sihua Yang,In vivo anatomical imaging of colorectum by tens-of-micron-resolved photoacoustic/ ultrasonic endoscope,Appl. Phys. Lett. 118, 153702 , 2021.
Zhongwen Cheng, Linghua Wu, Tengsen Qiu, Yihao Duan, Huan Qin*, Jun Hu*, and Sihua Yang*,An excitation-reception collinear probe for ultrasonic, photoacoustic, and thermoacoustic tri-modal volumetric imaging,IEEE Transactions on Medical Imaging , 3089243 , 2021.
Mingman Sun,Yuanzheng Ma, Zhuangzhuang Tong,Zhiyang Wang,Wuyu Zhang, and Sihua Yang*,High-security photoacoustic identity recognition by capturing hierarchical vascular structure of finger,J. Biophotonics , e202100086 , 2021.
Hui Sun, Wei Wang, Zixin Zhang , Li Wang, Wuyu Zhang , Kedi Xiong* and Sihua Yang,Real-time optical-resolution photoacoustic endoscope,Appl. Phys. Express 14 , 042012 , 2021.
2020年:
Chang Lu, Kedi Xiong*, Yuanzheng Ma, Wuyu Zhang, Zhongwen Cheng, and Sihua Yang*, Electrothermal-MEMS-induced nonlinear distortion correction in photoacoustic laparoscopy, Optics Express, 28(10), 15300, 2020.
Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Kedi Xiong, and Sihua Yang*, High-speed dual-view photoacoustic imaging pen, Optics Letters, 45(7), 1599-1602, 2020.
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Wuyu Zhang, and Sihua Yang*, Switchable optical and acoustic resolution photoacoustic dermoscope dedicated into in vivo biopsy-like of human skin, Appl. Phys. Lett., 116, 073703, 2020.
Fei Yang, Zhiyang Wang, Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Ying Gu, Haixia Qiu*, Sihua Yang*, Wide-field monitoring and real-time local recording of microvascular networks on small animals with a dual-raster-scanned photoacoustic microscope, J. Biophotonics, 2020; e202000022.
2019年:
Peng Lei, Xue Wen, Lei Wang, Pengfei Zhang* and Sihua Yang*, Ultrafine intravascular photoacoustic endoscope with a 0.7 mm diameter probe, Optics Letters, 44(22), 5406-5409, 2019.
Xin Wang and Sihua Yang*, Imaging of human wrist joint by a flexible-transducerbased morphological-adaptive photoacoustic tomography: a feasibility study, Chinese Optics Letters, 17(9), 091701, 2019.
Weicheng Zhang, Jiandong Li, Sihua Yang*, Real-time interleaved photoacoustic and ultrasound imaging for guiding interventional procedures, Applied Acoustics, 156, 1-6, 2019.
Xin Jin, Xinkun Wang, Kedi Xiong*, and Sihua Yang*, High-resolution and extended-depth-of-field photoacoustic endomicroscopy by scanning-domain synthesis of optical beams, Optics Express, 27(14), 19369, 2019.
Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Lan Zhang, Sihua Yang*, Miniaturized photoacoustic probe for in vivo imaging of subcutaneous microvessels within human skin, Quant. Imaging. Med. Surg., 9(5): 807-814, 2019.
Kedi Xiong, Wei Wang, Ting Guo, Zhen Yuan, and Sihua Yang*, Shape-adapting panoramic photoacoustic endomicroscopy, Optics Letters, 44(11), 2681-2684, 2019.
Xiaowan Li, Kedi Xiong*, and Sihua Yang*, Large-depth-of-field optical-resolution colorectal photoacoustic endoscope, Appl. Phys. Lett., 114, 163703, 2019.
Lei Wang, Peng Lei, Xue Wen, Pengfei Zhang, and Sihua Yang*, Tapered fiber-based intravascular photoacoustic endoscopy for high-resolution and deep-penetration imaging of lipid-rich plaque, Optics Express, 27(9), 12832, 2019.
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Kedi Xiong, and Sihua Yang*, Fast controllable confocal focus photoacoustic microscopy using a synchronous zoom opto-sono objective, Optics Letters, 44(7), 1880-1883, 2019.
Haigang Ma, Kedi Xiong, Junwei Wu, Xuanrong Ji, and Sihua Yang*, Noncontact photoacoustic angiography with an air-coupled ultrasonic transducer for evaluation of burn injury, Appl. Phys. Lett., 114, 133701, 2019.
2018年:
Ruian Liu, Liangzhong Xiang, Da Xing, Jiandong Li, Huan Qin, Weicheng Zhang, and Sihua Yang*, Large depth focus-tunable photoacoustic tomography based on clinical ultrasound array transducer, Appl. Phys. Lett., 113, 141102, 2018.
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Ying Gu, Tingwei Zhang, Haixia Qiu*, and Sihua Yang*, Fast linear confocal scanning photoacoustic dermoscopy for non-invasive assessment of chromatodermatosis, Appl. Phys. Lett., 113, 083704, 2018.
Qian Wang, Yujiao Shi*, Fen Yang, and Sihua Yang*, Quantitative photoacoustic elasticity and viscosity imaging for cirrhosis detection, Appl. Phys. Lett., 112, 211902, 2018.
Kedi Xiong, Sihua Yang*, Xiaowan Li, and Da Xing, Autofocusing optical-resolution photoacoustic endoscopy, Optics Letters, 43(8), 1846-1849, 2018.
Mingjun Xu†, Peng Lei†, Jianqin Feng, Fangfang Liu, Sihua Yang* and Pengfei Zhang*, Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment, Chinese Optics Letters, 16(3), 031702, 2018.
Zhongwen Cheng, Haigang Ma, Zhiyang Wang, and Sihua Yang*, 3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging, Chinese Optics Letters, 16(8), 081701, 2018.
Jiawei Sun, Quan Zhou and Sihua Yang*, Label-free photoacoustic imaging guided sclerotherapy for vascular malformations: a feasibility study, Optics Express, 26(4), 4967-4978, 2018.
Ning Liu, Sihua Yang* and Da Xing*, Photoacoustic and hyperspectral dual-modality endoscope, Optics Letters, 43(1), 138-141, 2018.
2017年:
Yujiao Shi, Sihua Yang*, Da Xing*, New insight into photoacoustic conversion efficiency by plasmon-mediated nanocaviataion: implications for precision theranostics, Nano Research, 10(8), 2800-2809, 2017.
Liewei Wen, Sihua Yang*, Junping Zhong, Quan Zhou, Da Xing*, Thermoacoustic imaging and therapy guidance based on ultra-short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles, Theranostics, 7(7):1976-1989, 2017.
Yujiao Shi, Sihua Yang*, Da Xing*, Quantifying the plasmonic nanoparticle size effect on photoacoustic conversion efficiency, Journal of Physical Chemistry C, 121(10), 5805-5811, 2017.
Haigang Ma, Sihua Yang*, Zhongwen Cheng, Da Xing*, Photoacoustic confocal dermoscope with a waterless coupling and impedance matching opto-sono probe, Optics Letters, 42(12), 2342-2345, 2017.
Dayang Jin, Fen Yang, Zhongjiang Chen, Sihua Yang*, and Da Xing, Biomechanical and morphological multi-parameter photoacoustic endoscope for identification of early esophageal disease, Applied Physics Letters, 111, 103703, 2017.
Shanshan Shang, Zhongjiang Chen, Yue Zhao, Sihua Yang* and Da Xing*, Simultaneous imaging of atherosclerotic plaque composition and structure with dualmode photoacoustic and optical coherence tomography, Optics Express, 25(2), 530-539, 2017.
2016年:
Liewei Wen, Wenzheng Ding, Sihua Yang*, Da Xing*, Microwave pumped high-efficient thermoacoustic tumor therapy with single wall carbon nanotubes, Biomaterials, 75, 163-173, 2016.
Yujiao Shi,Huan Qin,Sihua Yang,Da Xing*, Thermally confined shell coating amplifies the photoacoustic conversion efficiency of nanoprobes, Nano Research, 9, 3644-3655, 2016.
Hongjiang Chen†, Sihua Yang†, Ting Zhou, Jiankun Xu, Jun Hu*, Da Xing*, Synthesis and characterization of an HSP27-targeted nanoprobe for in vivo photoacoustic imaging of early nerve injury, Nanomedicine: Nanotechnology, Biology, and Medicine, 12, 1453-1462, 2016.
Qin H, Zhao Y, Zhang J, Pan X, Yang S*, Xing D*, Inflammation-targeted gold nanorods for intravascular photoacoustic imaging detection of matrix metalloproteinase-2 (MMP2) in atherosclerotic plaques, Nanomedicine: Nanotechnology, Biology, and Medicine, 12(7), 1765-1774, 2016.
Dong Xu, Sihua Yang, Ying Wang, Ying Gu*, and Da Xing*, Noninvasive and high-resolving photoacoustic dermoscopy of human skin, Biomedical Optics Express, 7(6), 2095-2102, 2016.
Zhongjiang Chen, Sihua Yang* and Da Xing*, Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging, Opt. Lett., 41(7), 1636-1639, 2016.
Junping Zhong, Sihua Yang, Liewei Wen, Da Xing, Imaging-guided photoacoustic drug release and synergistic chemo-photoacoustic therapy with paclitaxel-containing nanoparticles, Journal of Controlled Release, 226, 77-87, 2016.
Yating Wang, Dong Xu, Sihua Yang* and Da Xing*, Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector, Biomedical Optics Express, 7(2), 279-286, 2016.
2015年:
Conggui Chen, Yue Zhao, Sihua Yang* and Da Xing*, Mechanical characterization of intraluminal tissue with phase-resolved photoacoustic viscoelasticity endoscopy, Biomedical Optics Express, 6(12), 4975-4980, 2015.
Cuiyun Huang, Huan Qin, Jun Qian, Jingye Zhang, Shengyuan Zhao, Yinzhi Changyi, Bingbing Li, Jianping Zhang, Jianhua Zhu, Da Xing, Sihua Yang* and Cong Li*, Multi-parametric imaging of the invasivenesspermissive acidic microenvironment in human glioma xenografts, RSC Adv., 5, 55669, 2015.
Guo He#, Dong Xu#, Huan Qin, Sihua Yang* and Da Xing*, In vivo cell characteristic extraction and identification by photoacoustic flow cytography, Biomedical Optics Express, 6(10), 3748-3756, 2015.
Conggui Chen, Yue Zhao, Sihua Yang* and Da Xing*, Integrated mechanical and structural features for photoacoustic characterization of atherosclerosis using a quasi-continuous laser, Opt. Express, 23 (13), 17309-17315, 2015.
Xuanrong Ji, Kedi Xiong, Sihua Yang* and Da Xing*, Intravascular confocal photoacoustic endoscope with dual-element ultrasonic transducer, Opt. Express, 23 (7), 9130-9136, 2015.
Huan Qin, Ting Zhou, Sihua Yang* and Da Xing*, Fluorescence quenching nanoprobes dedicated to in vivo photoacoustic imaging and high-efficient tumor therapy in deep-seated tissue, Small, 11(22), 2675-86, 2015.
Guo He, Bingbing Li, Sihua Yang*, In vivo imaging of a single erythrocyte with high-resolution photoacoustic microscopy, Frontiers of Optoelectronics, 8(2), 122-127, 2015.
2014年:
Jian Zhang, Sihua Yang*, Xuanrong Ji, Quan Zhou, Da Xing*, Characterization of lipid-rich aortic plaques by intravascular photoacoustic tomography: ex vivo and in vivo validation in a rabbit atherosclerosis model with histologic correlation, Journal of the American College of Cardiology, 64(4), 385-390, 2014.
Yue Zhao,† Sihua Yang,† Conggui Chen, and Da Xing,*, Simultaneous optical absorption and viscoelasticity imaging based on photoacoustic lock-in measurement, Optics Letters, 39(9), 2565, 2014.
Bingbing Li, Huan Qin, Sihua Yang* and Da Xing*, In vivo fast variable focus photoacoustic microscopy using an electrically tunable lens, Optics Express, 22(17), 20130, 2014.
Junping Zhong, Sihua Yang*, Contrast-enhanced photoacoustic imaging using Indocyanine Green-Containing nanoparticles, Journal of Innovative Optical Health Sciences, 7(1), 1350029, 2014.
会议论文:
2019年:
· 第十四届全国激光技术与光电子学学术会,邀请报告. (上海, 3.17-20, 2019)
· The 11th CIOP, Invited Talk. (西安, 8.6-9, 2019)
· 2019年中国光学学会学术大会,邀请报告. (合肥, 8.9-12, 2019)
· 2019 Optoelectronics Global Conference, Invited Talk. (深圳, 10.3-6, 2019)
· 2019 Photonics Asia---生物医学光子产学研高峰论坛,执行主席. (杭州, 10.21, 2019)
· 第二届海峡两岸生物医学前沿交叉学术研讨会,邀请报告. (台湾新竹, 10.23-25, 2019)
2018年:
· 2018年光生物物理学术会议,邀请报告.(银川,7.11-13, 2018)
· PIERS 2018 Toyama,Invited Talk. (JAPAN, Toyama, August 1–4, 2018)
· 2018年生物医学工程年会, 邀请报告.(深圳,9.21-23, 2018)
· 8th Advanced Optical Methods, Invited Talk. ( 深圳, Nov. 4-7, 2018)
2017年:
· 第九届全国光学青年学术论坛, 邀请报告. (福州, 11.24-27, 2017 )
· The14th PIBM, Invited Talk. (苏 州, 9.26-28, 2017)
· The 9th CIOP, Invited Talk. (哈尔滨, 7.17-20, 2017)
· 全国生物医学工程大会, 邀请报告.(北京, 4.20-22, 2017)
· Asia Communications and Photonics Conference (ACP), Invited Talk. (广州, 11.10-13, 2017)
2016年及以前:
· The 8th CIOP, Invited Talk. (上海,7.18-20, 2016)
· Internatinoal Conference on Laser Applicatins in Life Sciences, Invited Talk (深圳,10.14-18, 2016)
· CLEO Pacific Rim 2015,邀请报告(韩国,釜山,2015.8)
· PIERS 2014, 邀请报告(广州,2014.8)
· International Conference on Laser Applications in Life,邀请报告(德国,乌尔姆,2014.7)
· 中国光学大会,邀请报告(长沙,2013.8)
· 国际生物物理和医学大会(SFM’12),大会报告(俄罗斯、萨若托夫,2012.9)
· 中国光学大会,大会报告(深圳,2011.9)
· 中国光学大会,口头报告(天津,2010.8)
· 生物医学工程高层论坛,邀请报告(上海,2010.5)
发明专利:
[1] 杨思华、王志阳、马海钢、程中文、邢达,一种同时多点激发与匹配接收的光声三维成像装置及方法,发明专利号:ZL 201710772485.X,申请日:2017-08-31;授权通知日:2020-2-24
[2] 杨思华、文学、雷鹏、邢达,一种用于光声超声血管内成像系统的快速插拔式光电耦合接头,发明专利号:ZL 201810487040.1,申请日:2018-05-21;授权公告日:2019-10-25
[3] 杨思华、程中文、马海钢、邢达,快速大视场高分辨率的光声/超声扇扫成像装置及其方法,发明专利号:ZL 201610788177.1;申请日期:2016-08-31;授权公告日:2019-06-4
[4] 杨思华、李林钢、熊科迪、邢达,一种用于光声扫描的电热式微镜的步进扫描控制装置及控制方法,发明专利号:ZL 201710004401.8,申请日期:2017-01-04;授权公告日:2019-05-07
[5] 杨思华、马海钢、邢达,一种多尺度光声显微成像装置及其方法,发明专利号:ZL 201610850278.7,申请日期:2016-09-26;授权公告日:2019-05-07
[6] 杨思华、马海钢、邢达,一种连续变焦超声探头及其变焦方法,发明专利号:ZL 201610508393.6;申请日期:2016-06-29;授权公告日:2019-02-01
[7] 杨思华、雷鹏、王聘聘、邢达,一体化的光声、超声、光声弹性内窥成像装置及其方法,发明专利号:ZL 201610298603.3,申请日:2016-05-06;授权公告日:2018-10-19
[8] 杨思华、杨芬、石玉娇、邢达, 光声定量弹性成像方法及装置,发明专利号:ZL 201510944323.0,申请日:2015-12-16;授权公告日:2018-09-11
[9] 杨思华、刘瑞桉、雷鹏、邢达,血管内光声吸收-弹性-粘性多模成像一体化内窥镜及其成像方法,发明专利号:ZL 201610795903.2;申请日:2016-08-31;授权公告日:2018-06-19
[10]杨思华、马海钢、许栋、邢达,用于光学-超声-光声多模显微成像的集成化扫描头,发明专利号:ZL201510400905.2,申请日:2015-07-09;授权公告日:2017-12-08
[11]杨思华、李林钢、熊科迪、邢达,一种组合式立体角扫描的光-声内窥成像装置及其方法,发明专利号:ZL201511026350.6,申请日:2015-12-29;授权公告日:2017-01-25
[12]杨思华、李冰冰、邢达,光声-荧光流式细胞仪,发明专利号:ZL 201210574155.5,申请日期:2012-12-26;授权公告日:2014-12-24
[13]杨思华、邢达、周求真,一种基于面阵超声探测器的快速三维光声成像系统及方法,发明专利号:ZL 201010139117.X,申请日期:2010-03-30;授权公告日:2014-12-10
[14]杨思华、陈重江、邢达,无超声换能器频带限制的光声成像装置及其检测方法,发明专利号:ZL 201210507448.3,申请日期:2012-12-04; 授权公告日:2014-11-05
[15]杨思华、张建、纪轩荣、邢达,聚焦式旋转扫描光声超声血管内窥成像装置及其成像方法,发明专利号:ZL 201210220399.5 申请日期:2012-06-28;授权公告日:2014-06-25
[16]杨思华、邢达,一种基于试剂显色差异的光声酸碱度成像方法及装置,发明专利号:ZL 200810219864.7;申请日:2008-12-11,授权公告日:2011-04-20
主要获奖:
2021年 2020年中国产学研合作创新与促进奖,产学研合作创新奖(个人)
2021年 2020年度广东省百名博士博士后创新人物
2020年 第九届“挑战杯”华南师范大学学生课外学术科技作品竞赛,特等奖
(王巍、文学、袁砚池;指导老师:杨思华、熊科迪)
2012年 教育部高等学校科学研究优秀成果奖二等奖(排名第三)
2008年 广东省科学技术奖(发明类)二等奖 (排名第三)
2007年 美国医学物理学会“Sylvia Sorkin Greenfield Award”(排名第一)
2007年 2007中国光学重要成果奖(排名第一)