个人简介
姓名:庄正飞
学历:博士
职称:教授级实验师
博导/硕导:博士生导师
研究方向: FRET显微成像系统开发与应用研究;光机电产品开发
电子邮箱: zhuangzf@scnu.edu.cn
通讯地址:广州天河区中山大道西55号
招生专业:
博士:物理学;
硕士:物理学,光学工程,光电信息工程,控制工程,仪器仪表工程,生物医学工程。
教育与工作经历:
2007 -至今:华南师范大学,教授级实验师
教学情况:
非线性光学(博士、硕士)、非成像光学(博士、硕士)
主持科研项目:
1. 国家自然科学基金,利用活细胞定量FRET成像技术研究PML调控肿瘤细胞铁死亡的分子机制;
2. 国家自然科学基金,拉曼光谱结合二次谐波成像技术对肾纤维化的早期诊断与定量分级研究;
3. 广东省特支计划科技创业领军人才;
4. 清远市人才创业项目,系列FRET分析测试仪的开发;
5. 教育部博士点基金,基于拉曼光谱与多光子成像技术的肾纤维化诊断与分级研究;
6. 广东省教育厅研究生联合培养基地项目,意识障碍多模态感觉刺激促醒系统;
7. 广东省自然科学基金,基于拉曼光谱与多光子成像的肾纤维化诊断与分级研究;
8. 广州南沙区工业与科技信息化局,家用光子亚健康调理仪产品的中试开发;
9. 广州市科技计划,拉曼光谱结合二次谐波成像技术对结直肠肿瘤的早期诊断与分化程度分级研究;
10. 公司横向合作项目,紫外到蓝光波段的光生物安全监测仪器研究;
11. 公司横向合作项目,智能护眼台灯及其光生物安全特性研究;
12. 公司横向合作项目,LED摄影灯具的研制与开发;
13. 公司横向合作项目,系列自动化设备的研制与开发。
参与重要科研项目:
14. 国家自然科学基金重点项目,基于结构光照明的动态超分辨定量FRET显微成像研究;
15. 广东省重大领域研发计划,荧光-FRET-无标记相位三模态活细胞超分辨成像系统的研制;
近五年发表的部分论文:
[1] Xiaoke Liu, Xuening Liu, Changpo Jiang, Zhihao Liu, Chaohui Zhuang, Min Hu, Zhengfei Zhuang*. A circadian lighting method for low blue light hazard, high color rendering index, and tunable circadian stimulus. Optics and Laser Technology. 2024, 168: 109794.
[2] Xuening Liu, Changpo Jiang, Xiaoke Liu, Zhihao Liu, Min Hu, Zhengfei Zhuang*. RGBW LED mixing temperature compensation method with high output consistency. Optics and Laser Technology. 2024, 171: 110440.
[3] Yue Ni, Hongce Chen, Qiuqiang Zhan, Zhengfei Zhuang*. Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis. Cellular Signalling, 2024, 121: 111278.
[4] Yue Ni, Hongce Chen, Xuecheng Cheng , Beini Sun, Zhirui Wu , Qiuqiang Zhan, Zhengfei Zhuang*. Hdm2 disrupts HdmX-mediated nuclear export of p53 by sequestering it in nucleus. Experimental Cell Research, 2024, 441(2): 114185.
[5] Yang Li, Yanxian Guo, Haolin Chen, Xia Xiao, Fangdong Long, Huiging Zhong, Kun Wang, Zhouyi Guo*, Zhengfei Zhuang*, Zhiming Liu*. Flexible wearable plasmonic paper-based microfluidics with expandable channel and adjustable flow rate for portable surface-enhanced Raman scattering sweat sensing. ACS Photonics. 2024, 11(2): 613-625.
[6] Shuo Wang, Min Hu, Beini Sun, Tian Pang, Zhengfei Zhuang*, Tongsheng Chen*. Dependence of ghost on the incident lightangle into dichroic mirror. Journal of Biophotonics. 2023, 16(11): e202300190.
[7] Shutong Liu, Limei Su, Han Sun, Tongsheng Chen, Min Hu, Zhengfei Zhuang*. Automated apoptosis identication in fluorescence imaging of nucleus based on histogram of oriented gradients of high-frequency wavelet coefficients. Journal of Innovative Optical Health Sciences. 2023, 16(02): 2244003.
[8] Han Sun, Chenshuang Zhang, Ye Yuan, Lu Gao, Shixian Zhai, Hongce Chen, Qilin Tang, Zhengfei Zhuang*, Tongsheng Chen*. Automated ExEm-spFRET microscope. Microscopy and Microanalysis. 2022, 28(2): 330–337
[9] Yang Li, Haolin Chen, Yanxian Guo, Kangkang Wang, Yue Zhang, Peilin Lan, Jinhao Guo, Wen Zhang, Huiqing Zhong, Zhouyi Guo*, Zhengfei Zhuang*, Zhiming Liu*. Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid. Photonics Reasearch. 2021, 9(6), 1039-1047.
[10] Lu Gao, Fangrui Lin, Danlu Han, Jieming Jiang, Chengwei Yang, Zhengfei Zhuang*, Tongsheng Chen*. Quantitative Fluorescence Resonance Energy Transfer Analysis on the Direct Interaction of Activation-2b with Histone H3/Switch-3B Protein in Arabidopsis Mesophyll Protoplasts. Journal of Fluorescence. 2021, 31:981-988.
[11] Ao Yin, Han Sun, Hongce Chen, Zhi Liu, Qiling Tang, Ye Yuan, Zhuang Tu, Zhengfei Zhuang*, Tongsheng Chen*. Measuring calibration factors by imaging a dish of cells expressing different FRET plasmids. Cytometry Part A. 2021, 99(6): 632-640.
[12] Zhi Liu, Zewei Luo, Hongce Chen, Ao Yin, Han Sun, Zhengfei Zhuang*, Tongsheng Chen*. Optical section structured illumination-based Förster resonance energy transfer imaging. Cytometry Part A. 2022, 101(3): 264-272.
[13] Han Sun, Ao Yin, Lu Gao, Hongce Chen, Qilin Tang, Ye Yuan, Zhi Liu, Zhengfei Zhuang*, Tongsheng Chen*. Measuring system calibration factors by unmixing the excitation-emission spectra of one dish of cells. Microscopy and Microanalysis. 2021, 27(6): 1498-1505.
[14] Haihong Yu, Zhengfei Zhuang, Dongling Li, Yanxian Guo, Yang Li, Huiging Zhong, Honglian Xiong, Zhi Liu*, Zhouyi Guo*. Photo-induced synthesis of molybdenum oxide quantum dots for surface-enhanced Raman scattering and photothermal therapy. Journal of Materials Chemistry B. 2020, 8(5): 1040-1048.
[15] Yanxian Guo, Zhengfei Zhuang, Zhiming Liu*, Wendong Fan, Huiqing Zhong, Wen Zhang, Yirong Ni, Zhouyi Guo*. Facile hot spots assembly on molybdenum oxide nanosheets via in situ decoration with gold nanoparticles. Applied Surface Science. 2019, 480: 1162-1170.
[16] Deqiu Huang, Zhengfei Zhuang, Zhen Wang, Shengtao Li, Huiqing Zhong, Zhiming Liu*, Zhouyi Guo*, Wen Zhang*. Black phosphorus-Au filter paper-based three-dimensional SERS substrate for rapid detection of foodborne bacteria. Applied Surface Science. 2019, 497: 143825.
获奖与荣誉:
(一)以第一指导教师获奖情况
1. FRET显微镜获得德国红点奖(Red Dot Award);
2. 指导学生罗泽伟等第一届粤港澳博士博士后创新创业大赛金奖;
3. 指导学生张旭东等获得广东省第十四届“挑战杯”大学生创业计划竞赛金奖;
4. 指导学生黄思奇获中国研究生能源装备创新设计大赛国赛三等奖;
5. 指导学生黄思奇获中国研究生“双碳”创新与创意大赛国赛三等奖;
6. 指导学生丁敏获得“中国光谷·华为杯”第十九届中国研究生数学建模竞赛三等奖;
7. 指导学生黄思奇获“中国龙腾奖”龙腾之星全球大学生绿色设计大赛铜奖;
8. 指导学生肖治宇等获生光院第二届课题设计与创新创业大赛特等奖;
9. 指导学生唐硕等获获得第九届“华炬杯”一等奖(第1名);
10. 第四届“青远杯”创新创业大赛教师组一等奖(第1名)。
(二)学术兼职:
广东省光学学会 副秘书长
国家半导体照明技术标准工作组TC203 委员
中国光学学会生物医学光子学专业委员会 委员
华南师范大学研究生培养指导委员会 委员
广东省光学学会激光医学与美容专业委员会 委员